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Pedro Madrigal Bayonas

SYSFLO Fellow at Polish Academy of Sciences

Pedro Madrigal Bayonas

Summary

Pedro Madrigal was a Marie Curie early stage research fellow at the Department of Biometry and Bioinformatics, Institute of Plant Genetics, Polish Academy of Sciences in Poznań, Poland. He developed several statistical packages for the analysis of ChIP-seq and DNase-seq datatsets, and collaborated with other partners within the SYSFLO consortium in the analysis and integration of next-generation sequencing data for the model plant Arabidopsis thaliana.

In October 2013, he joined Dr Ludovic Vallier's group, based in the Anne Mclaren Laboratory for Regenerative Medicine (LRM), University of Cambridge, and the Wellcome Trust Sanger Institute. The objective of the group is to study the functional impact of human genetic variation on pancreatic development and diabetes, pluripotency, neural development and reprogramming using human induced pluripotent stem cells (hIPSCs) and their differentiated derivatives as a model system. This project is part of the newly created cellular genetics programme at the Wellcome Trust Sanger Institute.

Research

My research interests include the study of a diverse range of protein-DNA interactions by next generation sequencing, and the development of computational and statistical methods to analyse the data to help understand the genetic mechanisms controlling variability in transcription networks and epigenetics (see Research Project page for more).

Brief Biography

I originally trained in computer science and telecommunications engineering, but moved quickly into bioinformatics.

During my studies at the Technical University of Cartagena, Spain, I integrated into MATLAB algorithms for image registration, segmentation and filtering based on the C++ open source ITK library. Subsequently, this project led to the realization of the Master thesis "Portal medical images preprocessing and registration with digitally reconstructed radiographies", aimed to reduce the radiation exposure over healthy tissues during radiotherapy treatment against cancer.

Between February and May 2009, I joined a training stay at the Nuclear Physics Institute in Cracow, Poland, within the Leonardo da Vinci European mobility programme. At the Department of Radiation Physics and Dosimetry I was involved in image reconstruction procedures applied to the resolution improvement of planar themoluminescence detectors, testing the software by evaluating 2-D distributions around radioactive sources.

After some months working in industry, I enrolled in the Marie Curie Initial Training Network SYSFLO at the Institute of Plant Genetics, Polish Academy of Sciences, under the supervision of Prof. Paweł Krajewski. Thanks to the scientific training provided by the SYSFLO network during the period 2010-2013, I was able to develop my bioinformatic skills. I gratefully acknowledge the European Commission for the opportunities given to young researchers in Europe through the Marie Curie grant program.

Contact

E-mail: pm12 [at] sanger.ac.uk

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